TNC and central nervous system cancer: Since, parallelism between association of proteolytic degradation of TN-C and poor prognosis in cancer including glioma (27, 28), we decided to focus on GBM next and tried to make it clear whether TNIIIA2 region, which is presumed to be released from TN-C digested by macrophage-derived MMP-9, play some roles in leading aggressive progression of tumor or not.