Additionally, 5xFAD mice (over-expressing in the brain the mutant human APP carrying Swedish, Florida, and London Familial Alzheimer’s Disease (FAD) mutations along with human PS1 harboring two FAD mutations) recapitulate significant AD and fecal microbial composition features that evolve with age (162, 163). This evidence concerns the gene PSEN1 and early-onset autosomal dominant Alzheimer disease.