TNF and major depressive disorder: In details, patients with SSD had higher levels in IL-18, IL-1Ra, TNF, and IL-6; whereas OCD patients had higher levels of IL-18, IL-1Ra, and TNF, compared to the healthy controls (248). Importantly, these effects were not caused by the presence of functional mutations of inflammasome components or products, which could lead to increased inflammasome activity and cytokine release, neither by the body mass index (BMI), age at disease onset, depression, or treatment with psychotropic drugs (248).