CD274 and neoplasm: TME metabolic constraints are known to increase myeloid-derived suppressive cells (3) (MDSCs) and regulatory T cells (Tregs) recruitment (4), as well as increasing inhibitory checkpoint molecule expression on immune cells such as PD-1, Programmed Death ligand-1 (PD-L1) (5) and CD47 a receptor part of the “don’t eat me signal” which avoids phagocytosis of tumor cells (6).