However, the opposing roles of IgE and IgG in food allergy extend significantly beyond these direct effects on effector cell activation, with immunoregulatory influences ranging from modulation of IgE receptor density and signaling thresholds in effector cells, to the IL-4-driven priming and maintenance of effective Th2 responses to food allergens and corresponding suppression and/or pathogenic reprogramming of Tregs. The gene discussed is IGHE; the disease is food allergy.