IGHE and peanut allergic reaction: For instance, patients undergoing OIT for peanut allergy in the PRROTECT trial had several log increases in levels of peanut-specific IgG1, IgG2, IgG3, IgG4, and IgA, as well as the ratio of peanut-specific IgG4/IgE with the greatest increases evident in peanut-specific IgG2 and IgG4 which were increased by two logs (139, 174).