As one of the key effector functions, C5a-induced C5aR1 activation, is involved in numerous kidney diseases, but also cardiac remodeling in hypertension (46, 47), psoriasis (48), rheumatoid arthritis (49), complications in sepsis (50), neuropathic pain (51), or hidradenitis suppurativa (52). The gene discussed is C5AR1; the disease is kidney disorder.