CD4 and COVID-19: Immune profiling of COVID-19 patients revealed distinct immunotypes with therapeutic implications, i.e. immunotype 1 characterized by a robust CD4 T cell activation, proliferating effector CD8 T cells was connected to severe disease, immunotype 2 with more traditional effector CD8 T cell subsets, less CD4 T cell activation and memory B cells, showed intermediate clinical outcome, and immunotype 3 with only minimal lymphocyte activation response showed the least clinical symptomatic picture (13).