NFKB1 and infection: showed in a human in vitro model that simulates the initial apical infection of alveolar epithelium with SARS-CoV-2 a rapid transcriptomic change in infected cells, characterized by a shift to an inflammatory phenotype with upregulation of NF-κB signaling and NF-κB target genes by day 1 post-infection, followed by a loss of the mature alveolar program (16).