The proportions of IFNγ+CD4+ and IFNγ+CD8+ T cells and the titers of IgG, IgM, and IgA against SARS-CoV-2 spike protein increased and inversely correlated with the SARS-Cov-2 viral load in surviving hypertensive patients with severe COVID-19. Here, CD40LG is linked to COVID-19.