CSTB is on locus 21q22.3, a region with previous CD implicated genes UBASH3A and ICOSLG (36, 38); MEF2BNB-MEF2B (BORCS8-MEF2B) is on 19p13.11, a locus harboring MYO9B with linkage to CD but with population-specific SNP variant association signals (33, 37); ARL11 and AARSD1 are on CD loci 13q14.2 and 17q21.31 respectively with no candidate genes previously identified (36). The gene discussed is CSTB; the disease is Cowden disease.