(9) indicated that minocycline improves diabetic retinopathy by inhibiting the TXNIP/NLRP3 inflammasome pathway, and vitamin D3 attenuates diabetic retinopathy by inhibiting high-glucose-induced ROS/TXNIP/NLRP3 inflammasome pathway (39). This evidence concerns the gene NLRP3 and diabetic retinopathy.