TNF and pulmonary fibrosis: Furthermore, two up-regulated genes (MT2A and EDN1) and 15 down-regulated genes (IL1B, CCR3, CXCL8, IL12B, TNF, CYSLTR2, FGF1, IL6, BMP7, MMP9, MUC5B, SFTPC, MECP2, TGFA, HMOX1) were associated with “lung fibrosis” pathway (Table 4 and Figure S8B).