A recent study showed that human epithelial cells infected with SARS-CoV-2 induces a high interferon response via Jak-STAT signaling pathway, which controls the viral replications and de novo virus production (56) Another study observed that type I IFNs suppress the SARS-CoV-2 activities in cultured cells, showing the potency of type I IFNs to treat COVID-19 (57). This evidence concerns the gene SOAT1 and COVID-19.