Figure 4A showed that CXCL2 and TNF induce neutrophil, while IL1A, IL1B, IL6, CXCL1, and TNF induce the T-helper cell. Enhance concentration of IL1A, IL1B, IL6, and TNF cause increase body temperature via the hypothalamus in COVID-19 (Figure 4A). The gene discussed is CXCL1; the disease is COVID-19.