IFNB1 and myeloid sarcoma: Thus, this study for the first time, showed that gut commensal P. histicola can suppress disease in HLA-DR3.DQ8 transgenic mice model of MS as effectively as IFNβ and both P. histicola and IFNβ utilize some common regulatory pathways including reduced activation of microglia, astrocytes and downregulation of pro-inflammatory immune response in the CNS.