SMAD3 and rheumatoid arthritis: Furthermore, the comparison between RA patients and OA patients has shown that the AUC was significant for FOXP3 (AUC 0.75, p<0.0001), SOCS1 (AUC 0.74, p = 0.001; Figure 8C), SMAD3 (AUC 0.66, p = 0.03) and RORc (AUC 0.65, p = 0.05) (Table 4S in Supplementary Files).