Comparison between RA patients and healthy subjects has shown that the area under curve (AUC Figure 8A) was significant for SOCS1 (AUC 0.75, p<0.0001), STAT3 (AUC 0.69, p = 0.002), SMAD3 (AUC 0.66, p = 0.007). The gene discussed is SOCS1; the disease is rheumatoid arthritis.