In addition, the similar cytokine response to exercise between groups suggests an exercise induced anti-inflammatory response that is intact even in the presence of excess adiposity. Second, compared to the NwAF, the ObAF had a significantly lower concentration of osteocalcin, both at rest and in response to acute exercise, suggesting that obesity during adolescence may blunt bone turnover, and thus prevent normal bone growth over time. Here, BGLAP is linked to obesity due to melanocortin 4 receptor deficiency.