A recent meta-analysis of individual patient data found a proportional increase in ICH risk in patients receiving tPA regardless of pre-specified subgroups such as age (≤80, >80 years old), treatment delay (≤3, 3–4.5, >4.5 h) and baseline stroke severity (NIHSS score 0–4, 5–10, 11–15, 16–21, ≥22), with non-significant interaction (39). The gene discussed is PLAT; the disease is stroke disorder.