SNCA and Parkinson disease: We observed a significantly increased odds ratios for PD and Parkinsonism with family history of PD or tremor (OR = 4.23; OR = 4.3 respectively), SNCA rs356219 (OR = 2.03 CC vs. TT for PD; OR = 2.48 CC vs. TT, OR = 1.85 TC vs. TT for Parkinsonism), being exposed to metals (OR = 2.37 for PD), being born in a farm (OR = 1.77; OR = 2.63 for PD and Parkinsonism respectively) and being born in the province of Brescia (OR = 1.7 for PD).