KL and kidney disorder: In virtually all kidney disease models including UUO, DN, adriamycin nephropathy, remnant kidney after 5/6 nephrectomy (5/6NX), ischemia/reperfusion injury (IRI) and cisplatin nephropathy, the expression of Klotho is markedly decreased in serum and the kidneys (Zhou et al., 2013; Zhou et al., 2015b).