SIRT1 and chronic kidney disease: In CKD, the mechanisms of resveratrol action include antioxidant activity, activating SIRT1 and PGC-1α and protecting mitochondrial function, anti-inflammation through suppressing TNF-α and NF-κB and inhibition of mTOR (Saldanha et al., 2013; Diaz-Gerevini et al., 2016).