Protein arginine N-methyltransferase 2 (PRMT2; HRMT1L1) is a member of the arginine methyltransferase family (Scott et al., 1998) that inhibits the resistance of breast cancer cells to tamoxifen by inhibiting the ERα36, PI3K, MAPK, and other signaling pathways (Shen et al., 2018). The gene discussed is PRMT2; the disease is breast carcinoma.