Moreover, infiltration of pro-inflammatory cytokines such as TNF-α, IL-1β, IL-6 and IL-17, inflammatory mediators augment like COX-2 and 5-LOX, reduction of anti-inflammatory factors such as IL-4 and IL-10, which have been positively related to RA, causes synovial inflammation and cartilage damage (Jing et al., 2019; Li et al., 2019c; Lin et al., 2013; Pan et al., 2017). This evidence concerns the gene IL4 and rheumatoid arthritis.