CSF2 and early-onset autosomal dominant Alzheimer disease: Abbreviations AD Alzheimer’s disease, SAL salidroside, SAMP8 senescence-accelerated mouse prone eight, Aβ beta-amyloid, NFTs neurofibrillary tangles, CNS central nervous system, SCFAs short-chain fatty acids, SAMR1 senescence-accelerated mouse resistant 1, OFT open field test, MWM Morris water maze, HE hematoxylin-eosin, IHC immunohistochemistry, IF immunofluorescence, IBA-1 ionized calcium binding adaptor molecule 1, APP amyloid precursor protein, IL interleukin, PCoA principal coordinate analysis, Th helper T cell, GM-CSF granulocyte-macrophage colony stimulating factor.