One study showed that systemic immune alterations trigger and drive the development of AD-related neuropathology, specifically Aβ accumulation and tau phosphorylation, as well as microglia and gliosis activation in wild-type mice, suggesting that immune reactions can precede AD-related pathology and may even be sufficient to cause it (Krstic et al., 2012). The gene discussed is MAPT; the disease is Alzheimer disease.