Emerging research has reported that lncRNA DLEU1 performed an indispensable role in the genesis and progression of various tumors such as gastric cancer, osteosarcoma, pancreatic ductal adenocarcinoma, non-small cell lung cancer, and breast cancer, as well as resistance to chemotherapy in tumors (Li X. et al., 2018; Chen X. et al., 2019; Gao et al., 2019; Zhang et al., 2019; Wang C. et al., 2019; Li Y. et al., 2019). Here, DLEU1 is linked to osteosarcoma.