We treated MV4-11 and HL-60 cells with quercetin in the presence of insulin/IGF-1 (acting as AKT activator) or VEGF.Compared with quercetin single administration, combined treatment with insulin/IGF-1 or VEGF significantly reduced the population of apoptotic cell in both AML cell lines (Figure 5A). The gene discussed is IGF1; the disease is acute myeloid leukemia.