According to the key role of VEGF in angiogenesis, this signaling pathway has been implicated as the central mediator of tumor neovascularization, and the interaction between VEGF and VEGFR2 has been demonstrated to be correlated to migration and differentiation of various tumor cells (Serrano et al., 2007; Jeanne and Jayesh, 2012). Here, VEGFA is linked to neoplasm.