In that study, Rahman et al. (2020) identified that pyruvate dehydrogenase (PDH) kinase (PDK)-2, a key regulator of the mitochondrial gatekeeping enzyme PDH, induces a metabolic shift from oxidative phosphorylation to glycolysis in astrocytes that contributes to neuroinflammatory responses characterized by increased levels of inflammatory cytokines (TNF-α, IL-1β, and IL-6) and gliosis; this further modulated the neuropeptidergic circuitry in the hypothalamus associated with altered feeding behavior in diabetes. Here, PDK2 is linked to diabetes mellitus.