In a moderate dry eye experimental model obtained after unilateral extraorbital lacrimal gland excision, Kurose et al. demonstrated by a single unit extracellular recording of trigeminal neurons (8–10 weeks after the surgery) that dry eye sensitized corneal cool cells to the TRPM8 agonist menthol and to cool stimulation (Kurose and Meng, 2013). The gene discussed is TRPM8; the disease is Keratoconjunctivitis sicca.