Adi1 encodes 1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase that is involved in methionine salvage: 5′-methylthioadenosine cycle to increase S-adenosylmethionine levels, which altered genome-wide promoter methylation profiles, resulting in altered gene expression in hepatocellular carcinoma (Chu et al., 2019). The gene discussed is ADI1; the disease is hepatocellular carcinoma.