Indeed, these in silico experiments have been essential to obtain a more detailed information about structural changes in biomolecules and, have been used to determine the structural dynamics of TTR (Ortore and Martinelli, 2012; Zhao and Lei, 2014), which in turn will be particularly relevant to the development of more targeted and effective therapies for the treatment of ATTR amyloidosis. The gene discussed is TTR; the disease is amyloidosis.