In addition to apoA-I, TTR is also involved on the cleavage of both neuropeptide Y (NPY) (Liz et al., 2009) and Aβ peptide (Costa et al., 2008), suggesting an important role of TTR-mediated proteolysis either in physiologic or pathologic conditions, with major impacts on the biology of nervous system and Alzheimer's disease, respectively (Liz et al., 2010). The gene discussed is TTR; the disease is early-onset autosomal dominant Alzheimer disease.