SYP and Alzheimer disease: Most neuronal markers [DCX (Tanapat, 2013), MAP2 (Tanapat, 2013), NEFM (Tanapat, 2013), NEFH (Tanapat, 2013), NEFL (Tanapat, 2013), RBFOX3 (Tanapat, 2013), SYP (Tanapat, 2013)] are significantly downregulated in AD temporal cortex samples from the MayoClinic dataset (Figure 1A).