CDK5 and Alzheimer disease: Moreover, genes that have previously been reported as playing a role in AD in the DisGeNet database, namely CDK5 (Liu et al., 2016), CDK5R1 (Moncini et al., 2017), FERMT2 (Shulman et al., 2014), and HSD17B10 (Marques et al., 2009), were actually found to be associated with neuronal loss rather than with the disease component (Figure 2D).