Indeed, perhexiline is involved in the inhibition of mTOR pathway which is related with autophagy, a process known to be altered in AD (Jaeger and Wyss-Coray, 2010), and panobinostat acts as an HDAC inhibitor, leading to the hypothesis that it may play a role similar to that of tubastatin-a. This evidence concerns the gene HDAC9 and Alzheimer disease.