In addition, alleles in HMGCR that lower LDL-C confer an increased risk of developing T2D and individuals with familial hypercholesterolemia are protected against T2D [34,47], leading to speculation that statins affect insulin sensitivity and insulin secretion [45,48], although the exact cellular and molecular mechanisms to such an increase in T2D risk are still not well understood. This evidence concerns the gene INS and familial hypercholesterolemia.