HMGCR and diabetes mellitus: Given, i) the high DE proximity and KD dominance scores, ii) the shared metabolic pathway, iii) the widespread use of statins (HMGCR inhibitors) as therapeutic drugs to lower cholesterol levels in patients with high LDL-cholesterol, and iv) the emerging role of HMGCR in energy balance, metabolism and diabetes risk [32–35], we sought to validate our KDA, both transcriptionally and functionally, focusing on HMGCR, FDPS and SQLE.