A statistically significant reduction in LC3 transcripts levels was seen going from CH (102.1±33.8) to PHCC (50.5 ± 24.8; q = 0.001), HCC (36.5±35.8; q = 0.0007), PM (q = 0.008) and M (q = 0.0007) (Fig 1F). This evidence concerns the gene MAP1LC3A and hepatocellular carcinoma.