It is interesting to observe the low LC3 transcript levels in both HCV- and HBV-related HCC and M. These data could be a consequence of an involvement of post-transcriptional or post-translational regulators, such as microRNAs, small non-coding RNAs, that can be overexpressed or downregulated in different phases of liver damage. Here, MAP1LC3A is linked to hepatocellular carcinoma.