PDE6B and retinal degeneration: Moreover, accumulation of LC3A/B+ autophagosomes and/or electron dense structures were not detected in other mouse models of retinal degeneration including the Rhodopsin T17M, Rd1, and Rds mutants (S5C and S5D Fig), suggesting a specific autophagic alteration in Rabgef1-KO retina unrelated to other mechanisms of photoreceptor cell death.