Since METTL14 has been reported to be reduced in patient HCCs, we speculate that METTL14 reduction could be involved in the downregulation of HNF3γ in HCCs.17 In further studies, a RIP assay validated the m6A modification of HNF3γ mRNA in HCC cells and confirmed the role of METTL14 in m6A modification of HNF3γ mRNA (Fig. 3c). This evidence concerns the gene METTL14 and hepatocellular carcinoma.