The mechanistic study on the synergistic effect of HNF3γ and sorafenib in HCC cell apoptosis demonstrated that HNF3γ upregulated OATP1B1 and OATP1B3 expression and thus enhanced sorafenib uptake, resulting in the enhanced sensitivity of HCC cells to sorafenib administration. Here, FOXA3 is linked to hepatocellular carcinoma.