Moreover, interference of OATP1B1 and OATP1B3 suppressed the HNF3γ-induced increase in sorafenib uptake (Fig. 7e), suggesting that HNF3γ might transactivate the expression of sorafenib influx transporters to enhance the sorafenib response in HCC cells (Fig. 7f). This evidence concerns the gene SLCO1B3 and hepatocellular carcinoma.