To identify the m6A reader required in m6A modification-regulated HNF3γ mRNA stability, we knocked down the m6A readers involved in RNA stability in HCC cells respectively.18 Our data showed that the interference of IGF2BP1, IGF2BP2, or IGF2BP3 (Fig. 3f and Supplementary Fig. S3g) but not YTHDF2, YTHDF3, or YTHDC2 (data not shown) resulted in the significant decrease of HNF3γ mRNA in HCC cells. This evidence concerns the gene IGF2BP2 and hepatocellular carcinoma.