SLCO1B1 and hepatocellular carcinoma: Moreover, interference of OATP1B1 and OATP1B3 suppressed the HNF3γ-induced increase in sorafenib uptake (Fig. 7e), suggesting that HNF3γ might transactivate the expression of sorafenib influx transporters to enhance the sorafenib response in HCC cells (Fig. 7f).