FOXA3 and hepatocellular carcinoma: Since METTL14 has been reported to be reduced in patient HCCs, we speculate that METTL14 reduction could be involved in the downregulation of HNF3γ in HCCs.17 In further studies, a RIP assay validated the m6A modification of HNF3γ mRNA in HCC cells and confirmed the role of METTL14 in m6A modification of HNF3γ mRNA (Fig. 3c).