CASP1 and COVID-19: NLRPs interact with ASC and caspase-1, forming multiprotein complexes called inflammasomes.48 Inflammasomes (e.g., NLRP1 and NLRP3) regulate the proteolytic processing of proIL-1β and proIL-18 into mature forms, and an inflammatory cell death termed pyroptosis.41 NLRP1/3, ASC, and caspase-1 expression have been confirmed in lung and vascular ECs.49,50 The NLRP3 pathway has been recently considered as a novel target for treatment of COVID-19.51