STAT1 and Cognitive impairment: As STAT1 acetylation played a key role in the nuclear localization and transcriptional activity of STAT3, we infected AAV-STAT1KR (410/413R-STAT1) with AAV-P301L virus into C57 mice and investigated whether non-acetylated STAT1 overexpression attenuated P301L-induced synaptic and cognitive deficits.