Since AP-1 is present in most activated specific open chromatin regions, the binding of AP-1 and the opening of chromatin during T cell activation are conducive to the formation of super enhancers, and the activity of AP-1 helps the activated T cells to form a specific epigenome.47 In our study, we found that active T cell immunity is the main immune feature during recovery from COVID-19, which is compatible with a strong AP-1 signaling. The gene discussed is JUNB; the disease is COVID-19.