LEF1 and COVID-19: The hub genes of the light cyan module were enriched in T cell differentiation, such as SATB1, LEF1, CCR7, CAMK4, IL6ST, TCF7, IL7R, SIRPG, and TMIGD2, and lncRNAs of CCR7-AS-1, LEF1-AS-1, LINC-CCR7-2, LINC-TCF7-1 and TCF7-AS -1, and most of them were mainly expressed in low-level differentiated T cells (Fig. 6d).24–27 The results showed that various clinical features affect the patient’s T cell immunity, but cannot change its tendency to become robust during recovery from COVID-19.