PTH and osteosarcoma: It is now believed that osteocytes orchestrate the bone remodeling by synthesizing and secreting crucial factors, such as sclerostin and RANKL.18–20 Cumulative evidence suggests that osteocytes might mediate the PTH anabolic activity in bone.21,22 A better understanding of how intermittent PTH functions will help develop strategies to improve its treatment and avoid its potential side effects, such as reduced therapeutic effect after long-term application, hypocalcemia, hypercalcemia, and osteosarcoma.