PTH1R plays critical roles in regulation of calcium metabolism, skeletal development, and homeostasis.1–10 Abnormalities in PTH/PTHrP/PTH1R signaling cause human diseases, such as hypercalcemia, osteoporosis, tumorigenesis, and metastasis.11,12 Therefore, it is important to understand how PTH1R is regulated under physiological and pathological conditions. The gene discussed is PTH; the disease is Hypercalcemia.