Although either Dmp1-Cre; Kindlin-2f//+ or Dmp1-Cre; Pth1rf//+ mice did not display marked osteopenia compared to their Cre-negative controls (data not shown), interestingly, we found that the double heterozygous mice (Dmp1-Cre; Kindlin-2f/+; Pth1rf/+) displayed marked osteopenia with significant reductions in BMD, BV/TV, Tb.N, and Tb.Th and increase in Tb.Sp, when compared to those in either singly heterozygous mice (Fig. 3a–d and supplementary Fig. 3). The gene discussed is DMP1; the disease is Osteopenia.