IL1B and rheumatoid arthritis: Moon et al. reported that the overexpression of DUSP5 reduced the expression IgG, IgG1, and IgG2a in a rheumatoid arthritis (RA) mouse model circulatory system by downregulating the activity of p-ERK and inhibiting the expression of tumor necrosis factor alpha (TNF-α) and IL-1β [34].