Analyzing patient fibroblasts that harbour the common mutations N370S, L444P, or the apparently unique D409H mutation in GBA that is associated with a unique clinical syndrome of cardiovascular disease did not indicate gross abnormalities in any of the catalytic activities, as tested with 4-MU-Glc and 4-MU-Xyl as substrates and cholesterol as the acceptor. This evidence concerns the gene GBA1 and cardiovascular disorder.