To determine if disease nonprogression in vertical HIV infection is associated with distinct HIV-specific IgG levels, we profiled IgG responses to recombinant HIV-1 consensus C p24, gp41, gp120, and gp140 antigens in HIV-infected pediatric nonprogressors (PNPs) in comparison to progressors or ART-treated children. The gene discussed is ITIH4; the disease is HIV infectious disease.