PTGS2 and neoplasm: Although it is possible some tumour cells could still be affected by the suppression of COX-2-PGE2 pathway, the data indicate an alternative and paracetamol-specific mechanism; DAC-induced mimicry of paracetamol overdose, leading to GSH depletion and exacerbated oxidative stress, both of which have the potential to restrict tumour growth and improve patient survival [36].