Importantly, the expression of gene sets identified behind the DAC and paracetamol interaction (namely, suppression of DAC-activated COX-2-PGE2 pathway, depletion of the GSH stores and thioredoxin response) significantly affects survival in HNSCC (Fig. 4N and Supplementary Table S6) and other cancers (Supplementary Table S7) in TCGA data sets. Here, PTGS2 is linked to head and neck squamous cell carcinoma.