ATP7A and amyotrophic lateral sclerosis: The fact that under- or over-expression of dATP7 and over-expression of either wildtype or M1311V hATP7A all induced similar locomotor deficits reminiscent of TDP-43 based models of ALS (Estes et al., 2011) in Drosophila larvae highlights the important role that precise regulation of ATP7A expression and, consequentially, copper homeostasis, plays in maintaining motor function.