This was true also in multivariable analysis adjusting for age, nodal status, tumour size, histological grade, ER, PR, HER2 and LVI (HRBCFi 0.22; 95% CI 0.11–0.43; P < 0.001 and HROS 0.23; 95% CI 0.11–0.48; P < 0.001). Here, ERBB2 is linked to neoplasm.