Among well described mitogen-activated protein kinases (MAPK) that are known to be widely expressed in PCa and involved in cell proliferation, invasion, cell-survival and cell cycling, we found extracellularly regulated kinase 1 and 2 (ERK1/2), p38, proto-oncogene tyrosine-kinase Src (Src) and 5′-AMP-activated protein kinase α (AMPKα) to be altered under the treatment (Fig. 4a-c) [23]. This evidence concerns the gene MAPK3 and posterior cortical atrophy.