The angiotensin-converting enzyme 2 (ACE2), hydroxychloroquine (HCQ) and chloroquine (CQ), interferons and the neutralizing antibodies have been postulated to play roles in the low prevalence of COVID-19 in malaria-endemic countries. The Africa Centers for Disease Control and Prevention (Africa CDC) has pioneered efforts to expand laboratory services in the Continent. The gene discussed is ACE2; the disease is COVID-19.