ACE2 is a negative regulator of the renin-angiotensin system (RAS), converting angiotensin (Ang) I and Ang II into Ang 1–9 and Ang 1–7, respectively [30] and, thus, protecting the cardiovascular system against systemic hypertension, myocardial infarction and diabetic cardiovascular complications [31, 32]. This evidence concerns the gene ANGPT1 and complication.