In Group 3 (postmenopausal osteoporosis, without fractures), the REL of: GSK3B and SFRP1 positively correlated with TH BMD (R=0.560, p = 0.046 and R=0.703, p = 0.007) and TH T-score (R=0.560, p = 0.046 and R=0.703, p = 0.007), respectively. Here, SFRP1 is linked to postmenopausal osteoporosis.