Interestingly, while LPS also increases KV1.3 and reduces P2X4 expression on microglia in vivo, both KV1.3 and P2X4 expression increase in parallel in the setting of ischemic stroke as shown by our laboratory on acutely isolated microglia from the infarcted brain hemisphere of mice subjected to ischemic stroke and by other groups on rodent and human microglia by immunohistochemistry or qPCR [5,12,43–46]. The gene discussed is P2RX4; the disease is ischemic stroke.