KCNA3 and ischemic stroke: However, we would like to point out here that in addition to numerous studies showing KV1.3 expression on microglia in rodents and humans by immunohistochemistry, the Kettenmann laboratory and our own group have repeatedly shown that increased KV1.3 expression on activated microglia is not just a tissue culture phenomenon and that Kv1.3 currents can be recorded from microglia in acute slices [30,31] and from acutely isolated microglia from the brains of 5xFAD mice [7] or from the infarcted area after middle cerebral artery occlusion [5,12], a model for ischemic stroke.