Similar to the earlier work, we also observed that KV1.3 inhibitors prevent microglia mediated neuronal killing in organotypic hippocampal slice cultures 3 days after microglia were activated either through 1-hour of hypoxia/aglycemia to simulate ischemic stroke [5] or by treatment with oligomeric amyloid-β to simulate microglia activation in AD [7]. Here, KCNA3 is linked to Alzheimer disease.