The results of our study showed that each α-hederin dose had no significant effect on the expression of glycolysis regulators Akt and p53 protein in tumour cells, while the expression of c-Myc and HIF-1α was significantly downregulated in each α-hederin group compared to the 0 μM α-hederin group (Figure 4). The gene discussed is HIF1A; the disease is neoplasm.