In two studies, miR1266 were found to be significantly higher in plaque psoriasis patients than in healthy controls and showed a correlation with PASI, suggested that the effect of miR-1266 on the pathogenesis of psoriasis was not through a regulation of IL-17A expression but through a more upstream signaling mechanism or miR-1266 is not likely to regulate IL-17A expression directly but may be involved in the pathogenesis of psoriasis by regulating other target molecules [12–13]. This evidence concerns the gene IL17A and psoriasis vulgaris.