Purified IgG from some of these PCOS subjects with elevated GnRHR‐AAb demonstrated a dose‐dependent effect on GnRHR activation in GnRHR‐transfected cells; and this in vitro activity was suppressed by the GnRHR antagonist Cetrorelix (Kem et al., 2020). This evidence concerns the gene GNRHR and polycystic ovary syndrome.