However, genes associated with cell differentiation (EPCAM, CK8, CK18, and FOXA2), EMT (SNAI1, FOSL1, and ID1), and cancer stem cells (CD44, CD133, ETV1, MALAT1, NEAT1, and NESTIN) displayed a more varied response compared to 2D cells. The gene discussed is KRT18; the disease is cancer.