Hypoxic exercise training has been shown to decrease arterial stiffness (Nishiwaki et al. 2010), metabolic risk factors like body fat (Haufe et al. 2008; Wiesner et al. 2009) and insulin resistance (Haufe et al. 2008; Mackenzie et al. 2011; Morishima et al. 2013), which all have been implicated in the pathogenesis of hypertension. Here, INS is linked to hypertensive disorder.